Kidney Fibrosis: Main Culprit for CRF or ESRF

What is kidney fibrosis?

Kidney fibrosis is the primary cause responsible for the development of various kidney diseases. It was fibrosis which leads to CRF or ESRF (End-stage Renal Failure), poses serious damages on kidneys and threatens patients’ life security.

Kidney fibrosis is characterized by the excess deposition of extracellular matrix (ECM), and its final result is glomerular sclerosis and renal tubulointerstitial fibrosis. The excess deposition of fibrous tissues gradually replaces the healthy ones, disrupts the normal renal structure resulting in the Kidney Failure.

After realizing the facts about kidney fibrosis, then what are the major incentives accounting for progression?

1. sustained hypertension

Reports have revealed that high blood pressure is the result of various kidney diseases, the other way round, it is also one vital factor involved in the kidney disease progression. Uncontrolled or poorly controlled high blood pressure is a bad sign for prognosis. What’s worse, elevated hypertension is an independent risky factor to ESRF.

2. poorly controlled proteinuria

Same as hypertension, massive proteinuria appears as not only the result of kidney disease, but also a crucial cause of kidney fibrosis. Heavy albuminuria signals patients a poor prognosis. This is especially true among the patients with primary membranous nephropathy.

3. infections

Infections are able to cause accelerated metabolism and pose extra burden on the impaired kidneys. The infection itself and bacterial endotoxin damages kidneys too. That’s why as one’s illness condition progresses all of a sudden, infection will be suspected as the first culprit.

4. Abnormal lipid metabolism

Hyperlipemia is one of the abnormal lipid metabolisms. It could speed up the glomerulosclerosis and kidney fibrosis.

Those four factors are the major incentives of the fibrosis. If you have diagnosed some kind of kidney diseases, or suffer from a sudden development of your disease condition, then you’d better pay more attention to those factors.

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