Is It Possible to Restore Kidney Function of FSGS

Focal Segmental Glomerulosclerosis (FSGS) is difficult to treat. Majority of patients with this disorder progress to ESRD over 5 to 20 years. In some cases, patients with an aggressive form of FSGS proceed to ESRD in 2 to 3 years. Conventional treatments involve steroids or other immunosuppressive drugs to help relieve the symptoms like Urine Protein. But these therapies fail to restore the overall renal function, so it is wise to find better comprehensive solutions.

FSGS is a kind of autoimmune disease mediated by immune cells. The infiltrating T cells in the glomeruli attack the kidney inherent cells directly or damage the epithelial cells by releasing vascular permeability factors. To treat this disease, we have to firstly control the immune reaction and at the same time remove the immune complex deposited in mesangial region.

For FSGS, the immune complex mainly consists of IgG and C3. This has been identified with series of immune tests. Only if we remove the immune complex deposited in the kidneys and recover the kidney function, can the disease be treated from the root. Otherwise, whenever we stop the steroids, the immune reaction will start again and the disease will relapse.

The fact is that, currently, there is not yet an effective medicine which can help us remove these deposits rapidly. Therefore, immune tolerance is developed to make our body temporarily co-exists with the immune complex so as to stop further inflammatory reaction. Small dose of immune blockers are given regularly to avoid the relapse of the disease. Besides, periodical evaluation of immune reaction in the kidneys can ensure the accuracy of immune blocking.

Immune tolerance is just a interim measure, in the following immune adjustment step, we will begin to remove the immune complex with Chinese medicines including oral medicine, Micro-Chinese Medicine Osmotherapy, and medicated bath.

Chinese medicine for nourishing Qi and blood can be used to strengthen immunity. Moreover, Micro-Chinese Medicine Osmotherapy is another therapy which can function to promote blood circulation and remove blood stasis. Chinese medicine is micronized into one thousandths granules. With the action of the microwave, they can arrive directly at the renal lesions through skin and channels on the back. More important, this remedy can help us activate the self-healing ability of the kidneys and provide necessary nutrients at the same time to speed up the repair of damaged renal cells. Consequently, kidney function of FSGS will get restored over time.

Why Creatinine Matters and What to Do about That

People with Renal Failure or ESRD live with high levels of creatinine. Elevated creatinine appears almost exclusively in people with the disease. Those patients are told that their creatinine level are dangerously high but don’t know what does that means or affects. If you are really a truth digger, then this may be the right article for you.

Creatinine is the metabolic product stemming from the muscle metabolism. It is excreted by kidneys exclusively, that’s why creatinine becomes the detection marker of kidney damages. A serum creatinine test can tell you how well your kidneys function, while a creatinine urine test measures the creatinine in your urine.

Ostensibly, the reason why creatinine would increase is due to malfunctioned kidneys failing to excrete urine. Substantially, it is caused by kidney fibrosis. The kidney fibrosis results from the occurrence of phenotype transformation as a result of damaged renal intrinsic cells. Fibroblasts change myofibroblasts on account of the stimulation of changes mentioned before. Meanwhile, healthy renal tissues are impaired and develop pathological changes. Consequently, Renal Failure appears in the end.

Due to the progressive damages of kidneys, one’s kidney function decreases accordingly. Of course, the excretory function declines and results in elevated creatinine. Moreover, other indexes such as serum creatinine and urea nitrogen rise too. High blood pressure and swelling attack in most of the patients with Renal Failure or kidney diseases.

After realizing how creatinine increases, you must want to know how to lower high levels of creatinine?

Some may already get the point that lowering the creatinine shouldn’t be the ultimate goal, compared with improving one’s kidney function, decreasing the high levels of creatinine should only be secondary. Because decreased kidney function or malfunctioned kidneys are the major culprits accounting for high levels of creatinine.

ESRD: 8 Reasons Explain Why Patient Suffer from Heart Failure

Heart failure forms often in people with End-stage Renal Disease (ESRD). If ESRD patients experience fatigue and dizziness, you may have heart failure and you still know nothing about it. Why would that happen? And what are the causes of heart failure?

8 reasons explain the possible causes of heart failure in ESRD patients.

1. High blood pressure

Undoubtedly, high blood pressure contributes to heart failure or other heart disease induced by ESRD. It damages the heart health even in people without any kind of kidney disease.

2. Hardening of the arteries

This is the most frequent cause of heart failure. The disease starts with fat deposit in the arteries and then plaques is forming, which blocks the small arteries causing hardening of the arteries. People with ESRD experience a higher risk of suffering from heart failure.

Other reasons include:

3. Excessive blood volume

4. Influence of uremic toxins

5. Renal anemia

6. Imbalance of electrolytes and acidosis

7. Dialysis arteriovenous fistula

8. Atherosclerosis

Since we have known the close relationship between ESRD and heart failure, what should do to prevent the happening?

Try to lower the high blood pressure. Normal blood pressure is 130/85. As hypertension is one of the most important factors involving in the heart failure treatment, lowering the high levels of blood pressure is the right as well as effective move. Another suggestion for those with decreased kidney function and proteinuria, they may benefit from an even lower blood pressure of 125/75mmHg. Conversely, the reduced blood pressure may contribute to slow down the progression of kidney disease.

Detailed strategies include: follow a low salt diet, stay away from smoking, exercising more, decrease the amount of alcohol your drink, keep an eye open if you have a family history such as diabetes mellitus, take regular physical check, monitor your blood sugar regularly, lose weight and take medications.

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