How Does Kidney Disease Attack

Vast majority of the kidney disease is some kind of immune disease. There are two major stages of kidney problems: first one is stage of inflammatory response, i.e. nephritis; the second stage is Renal Failure.

Several basic factors inducing kidney problems contain one’s emotion, diet, genetic factors, overwork and environment. Unstable emotion, unhealthy dietary habit, genetic influences, pressure from overwork causing mental stress and the influencing elements all are responsible for the occurrence of kidney disease. But I don’t mean kidney problem will probably occur. Abnormal immune system is the real culprits accounting for later nephritis. What are the results of abnormal immune system or disordered immunity? Obviously, chaotic immune system release antigens and antibodies, which form immune complexes. Under normal circumstance, those complexes can be removed out from blood by our immune system, but now it fail to function well. So those immune complexes will deposit in kidneys.

The deposited foreign matters would trigger hyperactive inflammatory response and damages intrinsic cells and normal renal structure. Consequently, proteinruia, blood in urine and occult blood occur.

If this situation fails to be well controlled, collagenous fiber of ECM forms as a result. Renal structure changes and filtering function is affected. Kidney fibrosis and hardening would develop along with decreased kidney function. Too much deposited immune complexes and proteinuria also could lead to further kidney damages. GFR decreases, creatinine elevates, anemia and high blood pressure appear subsequently. Renal Failure develops eventually.