Why Creatinine Matters and What to Do about That

People with Renal Failure or ESRD live with high levels of creatinine. Elevated creatinine appears almost exclusively in people with the disease. Those patients are told that their creatinine level are dangerously high but don’t know what does that means or affects. If you are really a truth digger, then this may be the right article for you.

Creatinine is the metabolic product stemming from the muscle metabolism. It is excreted by kidneys exclusively, that’s why creatinine becomes the detection marker of kidney damages. A serum creatinine test can tell you how well your kidneys function, while a creatinine urine test measures the creatinine in your urine.

Ostensibly, the reason why creatinine would increase is due to malfunctioned kidneys failing to excrete urine. Substantially, it is caused by kidney fibrosis. The kidney fibrosis results from the occurrence of phenotype transformation as a result of damaged renal intrinsic cells. Fibroblasts change myofibroblasts on account of the stimulation of changes mentioned before. Meanwhile, healthy renal tissues are impaired and develop pathological changes. Consequently, Renal Failure appears in the end.

Due to the progressive damages of kidneys, one’s kidney function decreases accordingly. Of course, the excretory function declines and results in elevated creatinine. Moreover, other indexes such as serum creatinine and urea nitrogen rise too. High blood pressure and swelling attack in most of the patients with Renal Failure or kidney diseases.

After realizing how creatinine increases, you must want to know how to lower high levels of creatinine?

Some may already get the point that lowering the creatinine shouldn’t be the ultimate goal, compared with improving one’s kidney function, decreasing the high levels of creatinine should only be secondary. Because decreased kidney function or malfunctioned kidneys are the major culprits accounting for high levels of creatinine.